SUMMARY:

Larynx cancer is the most common type of cancer in the head and neck region. The vast majority of these are
epidermoid cancer. Although the disease is mainly seen in older people, it is also found in the late 30s. Chemotherapy is also used in the treatment of the disease with surgery and radiotherapy methods. In some cases, chemotherapy is the only option. The treatment of this disease, which is highly mortal especially in the advanced stages, is not successful enough with chemotherapy alone. Studies on the treatment of thymoquinone which is involved in the structure of the seeds of Nigella sativa L. (black seed) and propranolol that is commonly used as a non-selective beta-adrenergic receptor blocker are promising on cancer treatments. No information is available on the combined use of these two active agents for cancer treatment. In our planned study, the effect of single and combined effects of thymoquinone and propranolol on epidermoid larynx cancer cell line (Hep-2) will be investigated experimentally by using cell culture techniques. We also aim to investigate the synergic effect of propranolol and thymoquinone in combination with cisplatin that is widely used in the treatment of the disease. The data to be obtained as a result of this research can lead to new combined drug treatment for the patients by whom the first options are surgery and radiotherapy.

02/01/2018 →